Purpose. Using rat conjunctival bleb model, we correlated changes morphology and histology in the bleb with changes in MMP-2\nand TIMP-2 levels. Methods. Filtering surgeries were performed on rats. Dynamic changes inmorphology and histopathology were\nobserved using HE staining. Expression of MMP-2 and TIMP-2 was determined by immunofluorescence microscopy and western\nblotting. Results.Well-elevated filtering blebs formed and persisted for an average of 12 days. Histological examination showed that\ninflammatory was dominant in postoperative days 1ââ?¬â??3, and proliferating manifestation became the main sign 5 days later.Western\nblot showed that MMP-2 was downregulated 1 day after surgery, upregulated at 3 days, and observed with a peak at 7 days; then it\npersisted until 28 days. The difference was statistically significant (F = 280.18,
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